David R Lynch Selected Research

Friedreich Ataxia (Friedreich's Ataxia)

5/2022	In vivo assessment of OXPHOS capacity using 3 T CrCEST MRI in Friedreich's ataxia.
4/2022	Friedreich's Ataxia related Diabetes: Epidemiology and management practices.
1/2022	Cerebellar Pathology in an Inducible Mouse Model of Friedreich Ataxia.
1/2022	Frataxin deficiency lowers lean mass and triggers the integrated stress response in skeletal muscle.
1/2022	Simultaneous Quantification of Mitochondrial Mature Frataxin and Extra-Mitochondrial Frataxin Isoform E in Friedreich's Ataxia Blood.
1/2022	Bone Mineral Density and Current Bone Health Screening Practices in Friedreich's Ataxia.
1/2022	DNA methylation in Friedreich ataxia silences expression of frataxin isoform E.
12/2021	Designing phase II clinical trials in Friedreich ataxia.
11/2021	Targeting 3' and 5' untranslated regions with antisense oligonucleotides to stabilize frataxin mRNA and increase protein expression.
6/2021	Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions.

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David R Lynch Research Topics

Disease

77	Friedreich Ataxia (Friedreich's Ataxia) 05/2022 - 05/2002
22	Neurodegenerative Diseases (Neurodegenerative Disease) 05/2022 - 01/2002
12	Encephalitis (Encephalitis, Rasmussen) 08/2018 - 01/2007
10	Cardiomyopathies (Cardiomyopathy) 06/2022 - 04/2008
9	Mitochondrial Diseases (Mitochondrial Disease) 12/2021 - 02/2005
9	Disease Progression 01/2021 - 07/2003
8	Ataxia (Dyssynergia) 06/2022 - 07/2006
6	Parkinson Disease (Parkinson's Disease) 03/2015 - 07/2003
6	Neoplasms (Cancer) 11/2014 - 01/2007
5	Anti-N-Methyl-D-Aspartate Receptor Encephalitis 08/2018 - 12/2008
4	Nervous System Diseases (Neurological Disorders) 01/2022 - 02/2005
3	Heart Diseases (Heart Disease) 04/2022 - 01/2018
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 11/2018
3	Rare Diseases (Rare Disease) 10/2019 - 01/2018
3	Schizophrenia (Dementia Praecox) 01/2019 - 03/2014
3	Teratoma (Teratoid Tumor) 08/2018 - 01/2007
3	Heart Failure 01/2018 - 01/2014
2	Central Nervous System Diseases (CNS Diseases) 01/2021 - 03/2015
2	Coenzyme Q10 Deficiency 01/2018 - 03/2008
2	Diabetes Mellitus 01/2017 - 03/2016
2	Opsoclonus-Myoclonus Syndrome (Kinsbourne Syndrome) 11/2016 - 09/2015
2	Insulin Resistance 11/2016 - 07/2014
2	Dementia (Dementias) 10/2014 - 08/2014
2	Neurologic Manifestations (Neurological Manifestations) 08/2014 - 03/2014
2	Psychotic Disorders (Schizoaffective Disorder) 08/2014 - 08/2012
2	Synucleinopathies 05/2005 - 08/2003
1	Scoliosis 06/2022
1	Hearing Loss (Hearing Impairment) 01/2021
1	Fatigue 01/2021
1	Headache (Headaches) 01/2021
1	Inflammation (Inflammations) 01/2021
1	Nausea 01/2021
1	Foot Deformities (Foot Deformity) 01/2019
1	Talipes Cavus (Pes Cavus) 01/2019
1	Ataxia with vitamin E deficiency 01/2018
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2018

Drug/Important Bio-Agent (IBA)

47	FrataxinIBA 06/2022 - 05/2002
18	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 08/2018 - 02/2005
14	Proteins (Proteins, Gene)FDA Link 05/2022 - 05/2002
13	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2022 - 10/2010
12	Biomarkers (Surrogate Marker)IBA 01/2021 - 11/2011
12	AntibodiesIBA 01/2018 - 01/2007
6	Adenine FDA LinkGeneric 01/2022 - 09/2012
6	IronIBA 01/2022 - 05/2002
6	GuanineIBA 01/2022 - 09/2012
4	Glucose (Dextrose)FDA LinkGeneric 04/2022 - 07/2012
4	SulfurIBA 01/2022 - 11/2017
4	idebenoneIBA 02/2012 - 04/2008
3	Protein Isoforms (Isoforms)IBA 01/2022 - 11/2018
3	omaveloxoloneIBA 01/2021 - 01/2019
3	Adenosine Triphosphate (ATP)IBA 01/2019 - 11/2017
3	Immunoglobulin G (IgG)IBA 08/2018 - 03/2014
3	AutoantibodiesIBA 08/2018 - 04/2010
3	EpitopesIBA 01/2018 - 06/2007
3	alpha-SynucleinIBA 09/2006 - 08/2003
3	CalpainIBA 06/2006 - 08/2003
2	EnzymesIBA 01/2021 - 02/2005
2	CalciumIBA 01/2021 - 02/2005
2	MicroRNAs (MicroRNA)IBA 06/2020 - 07/2012
2	Serine (L-Serine)FDA Link 01/2019 - 03/2014
2	serine racemaseIBA 01/2019 - 03/2014
2	coenzyme Q10 (CoQ10)IBA 01/2018 - 03/2008
2	RNA (Ribonucleic Acid)IBA 11/2017 - 07/2012
2	Surface Antigens (Surface Antigen)IBA 11/2016 - 09/2015
2	Insulin (Novolin)FDA Link 11/2016 - 07/2014
2	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 07/2014 - 03/2014
2	AMPA Receptors (AMPA Receptor)IBA 03/2014 - 04/2009
2	AntioxidantsIBA 07/2012 - 04/2008
2	Indicators and Reagents (Reagents)IBA 04/2012 - 06/2007
2	Pharmaceutical PreparationsIBA 08/2010 - 06/2009
2	AutoantigensIBA 04/2009 - 01/2007
2	Dopamine (Intropin)FDA LinkGeneric 09/2006 - 07/2003
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2021
1	Retinaldehyde (Retinal)IBA 01/2021
1	leriglitazoneIBA 01/2021
1	PPAR-gamma AgonistsIBA 01/2021
1	Aldehyde DehydrogenaseIBA 01/2021
1	IntegrinsIBA 01/2021
1	Vitamin A (Retinol)FDA LinkGeneric 01/2021
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	NucleotidesIBA 06/2020
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/2020
1	Methylprednisolone FDA LinkGeneric 11/2019
1	InterferonsIBA 01/2019
1	glucose-regulated proteinsIBA 01/2019
1	etravirine (TMC-125)FDA Link 01/2019
1	Interferon-gamma (Interferon, gamma)IBA 01/2019
1	Monoclonal AntibodiesIBA 08/2018
1	3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA)IBA 01/2018
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 01/2018
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2018
1	HDL LipoproteinsIBA 01/2018
1	HDL CholesterolIBA 01/2018
1	Simvastatin (Zocor)FDA LinkGeneric 01/2018

Therapy/Procedure

11	Therapeutics 04/2022 - 05/2002
4	Immunotherapy 10/2014 - 01/2007
3	Activities of Daily Living (ADL) 01/2021 - 03/2010
3	Drug Therapy (Chemotherapy) 10/2019 - 01/2009
2	Telescopes 08/2018 - 12/2002